Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

842
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
842

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Hydrophilic Brush Length and Hydrophobic Chain on Biodistribution of Polymethacrylate-Based Statistical Copolymers.

Biomacromolecules·2026
Same author

Antenna Tuning in Photoredox Nitric Oxide Releasers for Potent Photovasodilation.

Journal of medicinal chemistry·2026
Same author

Substituent effects on photoresponsive nitric oxide release by <i>N</i>-nitrosoaniline derivatives.

Organic & biomolecular chemistry·2026
Same author

CEPI Workshop Report: Applying Disease X Vaccine Library and Knowledge Base Approaches to Severe Fever with Thrombocytopenia Syndrome (SFTS).

Vaccines·2026
Same author

Neudesin modulates IGF1 and insulin signaling pathways by regulating the surface expression of IGF1R through a conserved WPE motif.

The FEBS journal·2026
Same author

Development of Liposomal Formulations Composed of Thermoresponsive Polymers to Enhance Tumor Accumulation in Combining with Local Tumor Heating.

Molecular pharmaceutics·2026

Related Experiment Video

Updated: Apr 23, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis
07:48

Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis

Published on: January 7, 2019

6.2K

Radiolabeled γ-polyglutamic acid complex as a nano-platform for sentinel lymph node imaging.

Kohei Sano1, Yuriko Iwamiya1, Tomoaki Kurosaki2

  • 1Department of Biomolecular Recognition Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 21, 2014
PubMed
Summary

A new biocompatible nano-platform, indium-111-labeled diethylenetriamine pentaacetic acid-poly(amidoamine) dendrimer/polyethyleneimine/γ-polyglutamic acid ((111)In-DTPA-G4/PEI/γ-PGA), shows promise for sentinel lymph node molecular imaging.

Keywords:
Molecular imagingNanoparticleSelf assemblySentinel lymph nodeγ-Polyglutamic acid

More Related Videos

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

1.0K
Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
09:06

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

1.8K

Related Experiment Videos

Last Updated: Apr 23, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis
07:48

Preparing a 68Ga-labeled Arginine Glycine Aspartate RGD-peptide for Angiogenesis

Published on: January 7, 2019

6.2K
Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

1.0K
Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
09:06

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression

Published on: February 3, 2023

1.8K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Imaging

Background:

  • Sentinel lymph node (LN) detection is crucial for cancer staging.
  • Developing safe and effective molecular imaging probes is essential for early detection.

Purpose of the Study:

  • To establish a safe and biocompatible nano-platform for molecular imaging.
  • To evaluate the effectiveness of a novel indium-111-labeled complex for sentinel LN imaging.

Main Methods:

  • A ternary anionic complex (DTPA-G4/PEI/γ-PGA) was synthesized and labeled with indium-111.
  • Cytotoxicity and erythrocyte agglutination were assessed.
  • In vitro cellular uptake by macrophage cells was evaluated.
  • In vivo biodistribution and sentinel LN visualization using SPECT were performed in rats.

Main Results:

  • The anionic (111)In-DTPA-G4/PEI/γ-PGA exhibited low cytotoxicity and minimal erythrocyte agglutination, indicating high biocompatibility.
  • (111)In-DTPA-G4/PEI/γ-PGA showed significant uptake by macrophage cells via phagocytosis and a γ-PGA-specific pathway.
  • In vivo studies demonstrated higher accumulation of (111)In-DTPA-G4/PEI/γ-PGA in sentinel LNs compared to the cationic counterpart.
  • SPECT imaging clearly visualized the sentinel LNs using the developed nano-platform.

Conclusions:

  • The developed anionic nano-platform (111)In-DTPA-G4/PEI/γ-PGA is safe and biocompatible.
  • This nano-platform is effective for molecular imaging of sentinel lymph nodes.
  • It holds potential for future clinical applications in cancer diagnostics.