Related Experiment Video
Updated: Jun 13, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
Published on: June 18, 2012
Antenna Tuning in Photoredox Nitric Oxide Releasers for Potent Photovasodilation
Daisuke Saitoh1, Sae Kitamura2, Naoya Ieda1,3
1Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan.
Abstract:
To realize spatiotemporal control of nitric oxide (NO), a key signaling molecule for vasodilation in biological systems, we previously developed photocontrollable NO releasers such as NORD-1, whose NO release is triggered by photoinduced electron transfer (PeT) to a light-harvesting moiety. Here, we aimed to improve the PeT-driven NO release by investigating the structure-activity relationship of the rhodamine antenna, focusing on modifications of amino groups at the 3-/6-positions and the element at the 10-position. NO release from selenium- or tellurium-containing NO releasers (NO-SeR and NO-TeR) was significantly enhanced, whereas a phospharhodamine-type NO releaser (NO-POR) exhibited no detectable photodecomposition. Quantum-chemical calculations suggested that the charge-transfer state for NO-POR is stabilized compared to other NO releasers. We confirmed that NO-TeR showed more efficient vasodilation than NORD-1 in ex vivo studies. These findings are expected to facilitate the design of new PeT-driven compounds for biological and therapeutic applications.
More Related Videos
08:21Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
Published on: July 21, 2023
08:23Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Related Concept Videos
Antihypertensive Drugs: Vasodilators
Nitric Oxide Signaling Pathway
Nuclear Overhauser Enhancement (NOE)
Photoreceptors and Visual Pathways