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Related Concept Videos

Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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To promote clear communication, for instance, about the location of a patient's abdominal pain or a suspicious mass, anatomists and clinicians typically use imaginary lines to categorize the abdominopelvic cavity into either four quadrants or nine regions to identify organs in the cavity.
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Updated: Apr 23, 2026

Laparoscopic Anatomical Liver Segment VII Resection with Liver Parenchymal Transection Following a Priority Approach
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Horizontal liver cleft: a rare anatomic variant.

Yong Han Ting1, Kian Soon Lim1

  • 1Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore, Singapore.

The American Journal of Case Reports
|September 21, 2014
PubMed
Summary
This summary is machine-generated.

A rare horizontal liver cleft, potentially from abnormal embryological development, was identified on CT scans. This anomaly challenges standard liver segmentation methods crucial for hepatobiliary surgery.

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Area of Science:

  • Radiology
  • Hepatobiliary Surgery
  • Embryology

Background:

  • Accurate preoperative radiological assessment of liver segments is vital for advanced hepatobiliary surgical techniques like segmental resection.
  • Conventional liver segmentation relies on imaginary planes along portal and hepatic veins.

Observation:

  • A 74-year-old female patient presented with a unique horizontal cleft dividing the liver into superior and inferior segments.
  • This cleft, observed on contrast-enhanced CT, contained the main portal veins and was present on prior imaging without history of liver surgery.

Findings:

  • This case represents the first reported instance of a horizontal liver cleft anomaly.
  • The anomaly is hypothesized to result from an early cessation of liver embryological development.

Implications:

  • The presence of a horizontal liver cleft can complicate standard liver segmentation techniques, such as Couinaud's classification.
  • Awareness of such anatomical variations is crucial for surgical planning and accurate radiological interpretation in hepatobiliary procedures.