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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
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Tau PET imaging in Alzheimer's disease
Nobuyuki Okamura1, Ryuichi Harada, Shozo Furumoto
1Department of Pharmacology, Tohoku University School of Medicine, 2-1, Seiryo-machi, Aoba-ku, Sendai, 9808575, Japan, nookamura@med.tohoku.ac.jp.
Current Neurology and Neuroscience Reports
|September 21, 2014
Summary
Detecting tau protein deposits in the brain using positron emission tomography (PET) imaging offers a noninvasive method for diagnosing and monitoring tauopathies. This technique aids in tracking disease progression and evaluating anti-tau therapies.
Area of Science:
- Neuroscience
- Medical Imaging
- Biomarker Development
Background:
- Tauopathies, including Alzheimer's disease, are characterized by tau protein accumulation, leading to neurodegeneration and cognitive decline.
- Noninvasive detection of tau pathology is crucial for diagnosis, disease tracking, and therapeutic assessment.
Purpose of the Study:
- To highlight the utility of tau positron emission tomography (PET) tracers for in vivo imaging of neurofibrillary pathology.
- To emphasize the requirements for effective tau PET tracers as biomarkers in Alzheimer's disease.
Main Methods:
- Development and application of novel tau PET tracers (e.g., T807, THK-5117, PBB3) for in vivo imaging.
- Utilizing PET imaging to assess the spatial distribution and longitudinal changes of tau deposition.
Main Results:
- Several tau PET tracers have demonstrated success in imaging neurofibrillary pathology in vivo.
- PET tau imaging allows for the longitudinal assessment of tau deposition patterns and their relationship with amyloid-beta pathology and neurodegeneration.
Conclusions:
- Tau PET imaging provides a valuable tool for diagnosing and monitoring tauopathies.
- This technology facilitates the evaluation of anti-tau therapies and supports the development of preventive interventions.
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