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Cellular and molecular basis of decision-making
Nilay Yapici1, Manuel Zimmer2, Ana I Domingos3
1Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY, USA.
EMBO Reports
|September 21, 2014
Summary
Molecular genetics is revealing the biological basis of decision-making. Studies in model organisms uncover cellular and molecular mechanisms driving choices in feeding, mating, and aggression.
Area of Science:
- Neuroscience
- Molecular Genetics
- Behavioral Biology
Background:
- Decision-making is a fundamental aspect of behavior studied by behavioral economists and neurophysiologists.
- Recent advances allow the investigation of decision-making at the molecular and cellular levels.
Purpose of the Study:
- To review recent research on the molecular and cellular mechanisms underlying decision-making.
- To explore how these mechanisms are studied in model organisms.
Main Methods:
- Analysis of molecular and cellular mechanisms in model organisms (mice, Drosophila melanogaster, Caenorhabditis elegans).
- Interrogation of decision-making processes related to food, sexual behavior, aggression, and foraging strategies.
Main Results:
- Identification of specific molecular and cellular pathways involved in various decision-making behaviors.
- Demonstration of conserved genetic and neural principles across different species.
Conclusions:
- Molecular genetics provides crucial insights into the biological underpinnings of decision-making.
- Understanding these mechanisms enhances our comprehension of the consilience between brain function and behavior.
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