Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

13.5K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
13.5K
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.8K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.8K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

13.3K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
13.3K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

6.3K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.3K
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

16.3K
Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
16.3K
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

12.0K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
12.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Angioedema Presenting as Infant-Onset Primary Lymphedema.

Journal of vascular anomalies·2026
Same author

Primary Upper Extremity Lymphedema Caused by a <i>CELSR1</i> Variant.

Journal of vascular anomalies·2026
Same author

Correction: MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome.

Acta neuropathologica communications·2026
Same author

Prenatal Lymphedema: A Genotype-Phenotype Analysis.

Journal of vascular anomalies·2026
Same author

Rheumatological Diseases and Lower Extremity Edema: A Lymphoscintigram Study.

Journal of vascular anomalies·2026
Same author

MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Apr 23, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
09:50

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

7.6K

Lymphedema.

Reid A Maclellan1, Arin K Greene1

  • 1Department of Plastic and Oral Surgery, Lymphedema Program, Boston Children׳s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115.

Seminars in Pediatric Surgery
|September 22, 2014
PubMed
Summary

Lymphedema is a chronic swelling caused by poor lymphatic function, leading to fluid buildup. Diagnosis involves examination and imaging, with management including compression, lifestyle changes, and sometimes surgery to improve lymphatic flow or reduce tissue size.

Keywords:
CompressionLymphedemaManagementPrimarySecondary

More Related Videos

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

13.8K
A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

5.9K

Related Experiment Videos

Last Updated: Apr 23, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
09:50

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

7.6K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

13.8K
A Murine Tail Lymphedema Model
04:38

A Murine Tail Lymphedema Model

Published on: February 10, 2021

5.9K

Area of Science:

  • Medical Science
  • Vascular Biology
  • Surgical Innovation

Background:

  • Lymphedema is characterized by chronic, progressive tissue swelling due to impaired lymphatic drainage.
  • Accumulation of protein-rich fluid in interstitial spaces leads to limb enlargement.
  • It is a distinct pathological condition, not merely a symptom of generalized swelling.

Purpose of the Study:

  • To provide a comprehensive overview of lymphedema diagnosis and management.
  • To differentiate lymphedema from other causes of extremity enlargement.
  • To discuss current and emerging therapeutic strategies.

Main Methods:

  • Diagnosis relies on clinical evaluation, patient history, physical examination, and lymphoscintigraphy.
  • Management strategies encompass conservative measures and surgical interventions.
  • Conservative care includes patient education, compression therapy, exercise, and skin care.

Main Results:

  • Effective management requires a multi-faceted approach tailored to individual patient needs.
  • Surgical options aim to restore lymphatic circulation or debulk excess tissue.
  • Surgical techniques include lymphatic-venous anastomosis, lymph node transfer, and liposuction.

Conclusions:

  • Lymphedema necessitates accurate diagnosis and a combination of conservative and surgical treatments.
  • Patient adherence to lifestyle modifications is crucial for long-term management.
  • Advancements in surgical techniques offer new hope for improving lymphatic function and reducing tissue burden.