Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethanolic Extract of <i>Bupleurum Falcatum</i> L. Root Attenuates Chronic Stress-Induced Cancer Metastasis via Inhibition of Src Kinase.

Nutrition and cancer·2026
Same author

Rosmarinic acid inhibits norepinephrine-induced metastatic capacity of triple negative breast cancer cells by Src kinase inactivation.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Development of a rapid and simple Xeno Nucleic Acid (XNA) sensor-based microRNA detection platform for Parkinson's disease diagnostics.

Journal of nanobiotechnology·2026
Same author

Refined obesity, smoking exposure, and lipid metrics in mortality risk assessment: a nationwide cohort analysis.

PloS one·2026
Same author

<i>Undaria pinnatifida</i> intake improves lipid metabolism in older women during marine healing: a nuclear magnetic resonance-based metabolomics analysis.

Nutrition research and practice·2026
Same author

Dehydration-induced condensation of AGO1 modulates miRNA functionality.

The Plant cell·2026

Related Experiment Video

Updated: Apr 23, 2026

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.8K

Paper-based bioactive scaffolds for stem cell-mediated bone tissue engineering.

Hyun-Ji Park1, Seung Jung Yu2, Kisuk Yang1

  • 1Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.

Biomaterials
|September 22, 2014
PubMed
Summary

This study introduces a novel paper scaffold for bone regeneration, enhancing stem cell therapy. The bioactive paper platform promotes bone repair and vascularized bone formation in vivo.

Keywords:
Bone tissue engineeringHuman adipose-derived stem cellInitiated chemical vapor depositionOsteogenic differentiationPaper scaffold

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.8K
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

9.5K

Related Experiment Videos

Last Updated: Apr 23, 2026

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering
09:49

Author Spotlight: Insights into the Use of Apple-Derived Cellulose Scaffolds for Bone Tissue Engineering

Published on: February 23, 2024

2.8K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.8K
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
09:32

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

9.5K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Bioactive, functional scaffolds are crucial for enhancing stem cell regenerative potential in tissue reconstruction.
  • Current limitations exist in scaffold materials for effective stem cell culture and transplantation.
  • Developing cost-effective and biocompatible scaffolds is essential for bone tissue engineering.

Purpose of the Study:

  • To develop and evaluate a paper-based bioactive scaffold for stem cell culture and transplantation for bone reconstruction.
  • To investigate the potential of paper as a functional scaffold for enhancing osteogenic differentiation and in vivo bone regeneration.
  • To explore the feasibility of using paper scaffolds for vascularized bone formation.

Main Methods:

  • Surface engineering of paper scaffolds using initiated chemical vapor deposition for polymer coating.
  • Assessment of scaffold stability, cell attachment, and compatibility with stem cell culture techniques.
  • Evaluation of structural, physical, and mechanical cues on human adipose-derived stem cells (hADSCs) osteogenic differentiation.
  • In vivo testing in a critical-sized calvarial bone defect model for bone regeneration and vascularization.

Main Results:

  • Engineered paper scaffolds demonstrated long-term stability and efficient cell attachment.
  • An optimal paper type enhanced osteogenic differentiation of hADSCs.
  • Bioactive paper scaffolds significantly improved in vivo bone regeneration in calvarial defects.
  • Stacked paper scaffolds promoted vascularized bone formation when combined with hADSCs and endothelial cells.

Conclusions:

  • Paper serves as a promising bioactive, functional, and cost-effective scaffold for stem cell-mediated bone tissue engineering.
  • This study presents the first report on the feasibility of paper materials for stem cell applications in tissue defect repair.
  • The developed paper scaffold platform offers a novel approach for regenerative medicine and bone reconstruction.