Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

200
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
200
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

267
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
267
Allergic Reactions02:06

Allergic Reactions

26.1K
Overview
26.1K
Hypersensitivities01:30

Hypersensitivities

7.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.2K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

258
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
258

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revised Baseline Series of the International Contact Research Group.

Dermatitis : contact, atopic, occupational, drug·2020
Same author

Best practices, new perspectives and the perfect emollient: optimizing the management of contact dermatitis.

The Journal of dermatological treatment·2017
Same author

Environmental airborne contact dermatoses.

Reviews on environmental health·2014
Same author

A comparison of the irritant and allergenic properties of antiseptics.

European journal of dermatology : EJD·2014
Same author

Historical perspective on the use of visual grading scales in evaluating skin irritation and sensitization.

Contact dermatitis·2011
Same author

Revised minimal baseline series of the International Contact Dermatitis Research Group: evidence-based approach.

Dermatitis : contact, atopic, occupational, drug·2011

Related Experiment Video

Updated: Apr 23, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

5.3K

Allergic contact dermatitis: clinical aspects.

Jean-Marie Lachapelle

    Reviews on Environmental Health
    |September 23, 2014
    PubMed
    Summary

    Understanding allergic contact dermatitis (ACD) involves recognizing the ACD syndrome. Differentiating ACD from irritant contact dermatitis is challenging, but patch testing and new complementary tests aid diagnosis.

    Area of Science:

    • Dermatology
    • Allergen Exposure

    Background:

    • Allergic contact dermatitis (ACD) presents complex clinical features.
    • Distinguishing ACD from irritant contact dermatitis solely on clinical presentation is difficult.
    • Hand eczema and photoallergic contact dermatitis require specific diagnostic considerations.

    Purpose of the Study:

    • To elucidate the multifaceted clinical aspects of allergic contact dermatitis.
    • To highlight the diagnostic challenges in differentiating ACD from irritant contact dermatitis.
    • To emphasize the importance of specialized conditions like hand eczema and photoallergic contact dermatitis.

    Main Methods:

    • Review of the concept of the ACD syndrome for clinical understanding.
    • Clinical assessment for differential diagnosis of contact dermatitis.

    More Related Videos

    Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
    08:25

    Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

    Published on: September 26, 2022

    3.3K
    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
    09:32

    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

    Published on: September 26, 2019

    6.6K

    Related Experiment Videos

    Last Updated: Apr 23, 2026

    A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
    08:02

    A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

    Published on: March 24, 2023

    5.3K
    Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
    08:25

    Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

    Published on: September 26, 2022

    3.3K
    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
    09:32

    Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

    Published on: September 26, 2019

    6.6K
  • Evaluation of diagnostic tools, including the gold standard patch test.
  • Consideration of recently developed complementary diagnostic tests.

    • Main Results:

    • The ACD syndrome provides a framework for understanding clinical lesions.
    • Clinical differentiation between irritant and allergic contact dermatitis is often challenging.
    • Patch testing is the established gold standard for ACD diagnosis.
    • Emerging complementary tests offer valuable diagnostic support.

    Conclusions:

    • A comprehensive understanding of the ACD syndrome is crucial for clinical practice.
    • Accurate diagnosis of ACD requires careful clinical evaluation and appropriate testing.
    • The patch test remains essential, complemented by newer diagnostic modalities.