Related Experiment Video
Updated: Apr 23, 2026

Imaging In-Stent Restenosis: An Inexpensive, Reliable, and Rapid Preclinical Model
Published on: September 14, 2009
Venous drug-eluting vs. bare-metal stenting: an experimental animal study using frequency domain optical coherence
Panagiotis M Kitrou1, Stavros Spiliopoulos, Konstantinos Katsanos
1Department of Diagnostic and Interventional Radiology, Patras University Hospital, Patras, Greece.
Introduction:
This protocol was designed to evaluate the safety and feasibility of implanting drug-eluting stents (DES), as well as to compare their long-term results versus bare-metal stents (BMS), in a rabbit venous model, using frequency-domain optical coherence tomography (FD-OCT).
Methods:
Thirteen New Zealand white rabbits underwent implantation of a zotarolimus-eluting stent in the iliac vein (DES Group) and a BMS in the contralateral iliac vein (BMS Group). The study's primary endpoints included technical success and the comparison of in-stent neointimal hyperplasia in the two study groups, using ex vivo FD-OCT, at 3 months.
Results:
Thirteen DES and 13 BMS were successfully implanted. The technical success rate was 100% (26/26 stents). Three animals (3/13, 23.0%) died within the first 45 days. The remaining 10/13 animals (77%) were euthanized on the 90th day following stent implantation. The 20 stents were successfully removed. Successful ex vivo FD-OCT was performed in all stent-implanted iliac vein segments, 10 in the DES Group and 10 in the BMS Group. There was no statistically significant difference in the mean neointimal thickness between the two groups (3.02 ± 1.19 mm2 in DES Group vs. 2.76 ± 1.17 mm2 in BMS Group; p=0.0501).
Conclusions:
In this experimental protocol, DES implantation in the venous system was safe and feasible. Hyperplasia thickness was similar in both groups after 3 months' follow up.
More Related Videos
11:12Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography
Published on: October 3, 2018
07:18Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
Related Concept Videos
Imaging Studies VII: Vascular Imaging
Imaging Studies for Cardiovascular System V: CT
Computed Tomography
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Acute Coronary Syndrome III: Diagnostic Studies
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT