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Extracellular vesicles as enhancers of virus vector-mediated gene delivery
Zachary Fitzpatrick1, Bence György, Johan Skog
11 Department of Neurology, The Massachusetts General Hospital , and Neuroscience Program, Harvard Medical School, Boston, MA 02129.
Abstract:
Extracellular vesicles (EVs) being released from two adjacent adeno-associated virus serotype 1 (AAV1)-producing 293T cells are shown by electron microscopy. We have shown that AAV vectors can associate with EVs and enter the media. Furthermore, we have recently reported that EV-associated AAV has robust gene delivery and antibody evasion properties in vivo.
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