Related Experiment Video
Updated: Aug 13, 2026
06:18
Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor
Published on: August 18, 2023
Real-World Data from a Single-Center, Large Academic Centralized Manufacturing of CD19 CAR T Cells in an Industry
Kati Kebbel1, Gerno Schmiedeknecht1, Andrea Quaiser1
1Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany.
Human Gene Therapy
|August 12, 2026
Abstract:
To date, prediction of manufacturing failure for CAR T cells is still lacking. In a retrospective multivariate analysis of our 368 manufactured CAR-T cell batches (tisagenlecleucel), we investigated potential factors that might be associated with manufacturing failure. In this letter to the editor, we provide a summary of our findings and outline recommendations for future advanced quality control strategies.
