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Related Experiment Video

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T2 Relaxation time quantitation differs between pulse sequences in articular cartilage.

Stephen J Matzat1, Emily J McWalter1, Feliks Kogan1

  • 1Radiology, Stanford University, Stanford, California, USA.

Journal of Magnetic Resonance Imaging : JMRI
|September 23, 2014
PubMed
Summary

This study compared T2 relaxation time measurements in knee cartilage using various MRI sequences. Fast SE (2D-FSE), quantitative double echo steady state (qDESS), and 3D magnetization-prepared spoiled gradient echo (3D-MAPSS) showed the best agreement with the reference standard.

Keywords:
T2 relaxation time mappingcartilagemagnetic resonance imagingpulse sequence

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Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Biomedical Engineering
  • Orthopedics

Background:

  • Accurate T2 relaxation time measurements are crucial for assessing articular cartilage health.
  • Different MRI pulse sequences may yield varying T2 values, impacting comparability across studies.
  • Evaluation of T2 quantification in articular cartilage at 3 Tesla is needed.

Purpose of the Study:

  • To compare T2 relaxation time measurements obtained from multiple MRI pulse sequences.
  • To assess the performance of various sequences against a reference standard in phantoms and in vivo.
  • To determine the most reliable sequences for cartilage T2 quantification at 3T.

Main Methods:

  • T2 relaxation times were measured in agar phantoms and knee articular cartilage of eight healthy individuals.
  • A single echo spin echo (SE) sequence served as the reference standard.
  • Five other sequences were evaluated: multi-echo SE (MESE), fast SE (2D-FSE), 3D-MAPSS, 3D vfl-FSE, and qDESS.

Main Results:

  • All sequences showed good correlation with the reference standard in phantoms (R² > 0.8).
  • For in vivo cartilage, 2D-FSE (R²=0.64), qDESS (R²=0.60), and 3D-MAPSS (R²=0.51) demonstrated the best fits with SE.
  • 3D-MAPSS, 3D vfl-FSE, and qDESS provided the closest average T2 measurements to the SE reference.

Conclusions:

  • 2D-FSE, qDESS, and 3D-MAPSS are recommended for reliable T2 quantification in articular cartilage due to strong agreement with SE.
  • The observed discrepancies highlight the need for careful consideration when comparing T2 relaxation time data across different MRI sequences and studies.
  • These findings aid in selecting optimal MRI protocols for cartilage assessment.