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Related Experiment Video

Updated: Apr 23, 2026

Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
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Oocyte versus embryo vitrification for delayed embryo transfer: an observational study.

Leyre Herrero1, Sandra Pareja1, Marina Aragonés1

  • 1IVI Madrid, Madrid, Spain.

Reproductive Biomedicine Online
|September 24, 2014
PubMed
Summary

Oocyte vitrification and embryo vitrification yield similar live birth rates in patients at risk for ovarian hyperstimulation syndrome. This study found comparable ongoing pregnancy and cumulative clinical pregnancy rates between the two methods.

Keywords:
ICSIembryooocyteovarian hyperstimulation syndromepregnancyvitrification

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • In Vitro Fertilization

Background:

  • Patients at risk for ovarian hyperstimulation syndrome (OHSS) often require fertility preservation.
  • Ovarian stimulation protocols can increase OHSS risk, necessitating careful management strategies.
  • Vitrification is a common cryopreservation technique for both oocytes and embryos.

Purpose of the Study:

  • To compare embryological and pregnancy outcomes between oocyte vitrification and embryo vitrification.
  • To evaluate the efficacy of these methods in patients susceptible to OHSS.
  • To determine if vitrification timing impacts reproductive success.

Main Methods:

  • An observational prospective study involving 96 patients at risk for OHSS.
  • Patients were divided into two groups: oocyte vitrification (Group 1) and embryo vitrification (Group 2).
  • Key outcomes including implantation, clinical pregnancy, abortion, ongoing pregnancy, and live birth rates were analyzed.

Main Results:

  • No significant differences in baseline characteristics were observed between the groups.
  • Implantation rates were 30.6% (oocyte) vs. 33.1% (embryo); clinical pregnancy rates were 41.9% vs. 7.1%, respectively.
  • Similar cumulative clinical pregnancy rates (62.0% vs. 69.6%), ongoing pregnancy rates (56.0% vs. 54.3%), and live birth rates (72.0% vs. 69.6%) were achieved.

Conclusions:

  • Oocyte vitrification is a viable alternative to embryo vitrification, offering comparable live birth rates.
  • Both methods demonstrate similar success rates in patients requiring OHSS risk management.
  • Vitrification timing did not significantly affect the observed reproductive outcomes.