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Updated: Apr 23, 2026
A Novel Scalp Acupuncture-based Method to Target the Hand Motor Hotspot for Non-invasive Brain Stimulation
Published on: December 19, 2025
Localizing hand motor area using resting-state fMRI: validated with direct cortical stimulation.
Tian-ming Qiu1, Chao-gan Yan, Wei-jun Tang
1Neurological Surgery Department, Huashan Hospital, Shanghai Medical College, Fudan University, 12#, Wulumuqi Zhong Road, Shanghai, 200040, People's Republic of China.
Resting-state fMRI (R-fMRI) shows high sensitivity and specificity for mapping the hand motor area, comparable to task-based fMRI (T-fMRI). R-fMRI offers a convenient alternative for presurgical planning in patients with brain tumors.
Area of Science:
- Neuroimaging
- Neurosurgery
- Clinical Neuroscience
Background:
- Resting-state functional magnetic resonance imaging (R-fMRI) is a valuable tool for clinical applications, particularly in presurgical mapping for neurosurgery.
- This study evaluated the diagnostic accuracy of R-fMRI for localizing the hand motor area in brain tumor patients.
Observation:
- Direct cortical stimulation (DCS) served as the gold standard for validating the hand motor area.
- R-fMRI and task-based fMRI (T-fMRI) were compared against DCS findings in 17 patients.
Findings:
- R-fMRI demonstrated high sensitivity (90.91%) and specificity (89.41%) for hand motor area localization.
- T-fMRI showed slightly lower sensitivity (78.57%) and specificity (84.76%), with no statistically significant difference compared to R-fMRI.
Implications:
- R-fMRI is a highly sensitive and specific method for presurgical mapping of the hand motor area.
- Its convenience makes R-fMRI a promising alternative to T-fMRI, potentially improving patient experience during neurosurgical planning.
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