Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Consensus on acromegaly complications: an update.

Pituitary·2026

Same author

Impulse control disorders and dopamine agonists.

Best practice & research. Clinical endocrinology & metabolism·2026

Same author

Biomarkers of Leucine-Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy.

Movement disorders : official journal of the Movement Disorder Society·2026

Same author

Somatic mosaicism in ALS and FTD identifies focal mutations associated with widespread degeneration.

Nature genetics·2026

Same author

A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Nature genetics·2026

Same author

Distribution, severity, and management of joint pain in patients with acromegaly.

European journal of endocrinology·2026

Same journal

Preface.

Handbook of clinical neurology·2026

Same journal

Foreword.

Handbook of clinical neurology·2026

Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026

Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026

Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026

Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 23, 2026

Endoscopic Approach for Colloid Cyst Resection

Endoscopic Approach for Colloid Cyst Resection

Published on: May 23, 2025

Rathke's cleft cyst.

Sarah Larkin¹, Niki Karavitaki², Olaf Ansorge¹

¹Department of Neuropathology, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Handbook of Clinical Neurology

|September 25, 2014

Summary

This summary is machine-generated.

Rathke's cleft cysts are benign sellar lesions typically found in adults. Surgical removal is the standard treatment, though recurrence factors remain uncertain.

Keywords:

Rathke's cleft cyst diabetes insipidus endocrine dysfunction headache visual disturbance

More Related Videos

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Published on: February 28, 2025

Author Spotlight: Double Posteromedial Approach for Treating Posterior Cruciate Ligament Cysts

Author Spotlight: Double Posteromedial Approach for Treating Posterior Cruciate Ligament Cysts

Published on: October 20, 2023

Related Experiment Videos

Last Updated: Apr 23, 2026

Endoscopic Approach for Colloid Cyst Resection

Endoscopic Approach for Colloid Cyst Resection

Published on: May 23, 2025

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Laparoscopic Choledochal Cyst Excision and Roux-en-Y Choledochojejunostomy in Adults

Published on: February 28, 2025

Author Spotlight: Double Posteromedial Approach for Treating Posterior Cruciate Ligament Cysts

Author Spotlight: Double Posteromedial Approach for Treating Posterior Cruciate Ligament Cysts

Published on: October 20, 2023

Area of Science:

Neuroscience
Endocrinology
Pathology

Background:

Rathke's cleft cysts (RCCs) are benign sellar/suprasellar lesions originating from Rathke's pouch remnants.
They peak in incidence between 30-50 years, with most measuring 10-20mm and containing mucoid material.
While often asymptomatic, RCCs can present with headaches, visual disturbances, or pituitary hormone abnormalities.

Purpose of the Study:

To review the characteristics, presentation, and management of Rathke's cleft cysts.
To discuss the diagnostic imaging features, particularly MRI findings.
To identify factors influencing the recurrence of Rathke's cleft cysts post-treatment.

Main Methods:

Literature review of Rathke's cleft cysts, focusing on clinical presentation, imaging, and treatment outcomes.
Analysis of histopathologic features and potential relationship with craniopharyngiomas.
Examination of factors associated with cyst recurrence after surgical intervention.

Main Results:

Rathke's cleft cysts are characterized by variable content (clear fluid to mucoid material) and MRI signal intensity.
Surgical resection is the primary treatment, aiming for cyst content drainage and capsule removal.
Recurrence risk factors include cyst size, squamous metaplasia, incomplete resection, and intraoperative CSF leak.

Conclusions:

Rathke's cleft cysts are generally benign but require careful management due to potential recurrence.
Accurate diagnosis via MRI and complete surgical resection are crucial for successful outcomes.
Further long-term follow-up studies are needed to fully elucidate recurrence patterns.