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[Drug induced hepatotoxicity in targeted therapy for lung cancer]

Xueqin Chen1, Shaoyu Yang1, Shenglin Ma1

  • 1Department of Medical Oncology, Affiliated Hangzhou Hospital (Hangzhou First People's Hospital), Nanjing Medical University, Hangzhou 310006, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|September 25, 2014
PubMed

Insights

Targeted therapies like Gefitinib for non-small cell lung cancer offer benefits but can cause liver damage. This review examines drug-induced hepatotoxicity and its underlying mechanisms.

Area of Science:

  • Oncology
  • Pharmacology
  • Toxicology

Context:

  • Targeted therapies targeting driver genes are crucial for advanced non-small cell lung cancer (NSCLC).
  • Drugs such as Gefitinib, Erlotinib, and Crizotinib are standard treatments for NSCLC.
  • These targeted drugs are associated with increased risks of hepatotoxicity.

Purpose:

  • To review the mechanisms of drug-induced liver injury (DILI) in NSCLC patients.
  • To discuss the clinical presentation and management of DILI associated with targeted therapies.
  • To highlight the importance of monitoring liver function during treatment.

Summary:

  • Gefitinib, Erlotinib, and Crizotinib are effective in treating advanced NSCLC by targeting specific driver genes.
  • Hepatotoxicity is a significant adverse effect of these targeted drugs.
  • Understanding the mechanisms of DILI is essential for mitigating risks and improving patient outcomes.

Impact:

  • Provides a comprehensive overview of DILI in the context of NSCLC targeted therapy.
  • Aids clinicians in identifying and managing liver-related adverse events.
  • Contributes to safer and more effective cancer treatment strategies.

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