Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
Community Based Intervention01:30

Community Based Intervention

612
Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
612
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

1.2K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.2K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

872
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
872
Long-term Depression01:05

Long-term Depression

27.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.2K
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

2.0K
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multimodal evaluation of transcranial photobiomodulation in mild cognitive impairment: Cognitive, metabolic, and neuroimaging outcomes of a pilot randomized controlled trial.

Journal of Alzheimer's disease : JAD·2026
Same author

Resilience and Burnout Among Healthcare Staff During COVID-19: Lessons for Pandemic Preparedness.

Healthcare (Basel, Switzerland)·2026
Same author

The Registered Practical Nurse (RPN) Role in an Academic Acute Care Hospital: A Mixed Method Study of the Barriers and Facilitators to Practice.

Journal of nursing management·2025
Same author

Social media strategies used to translate knowledge and disseminate clinical neuroscience information to healthcare users: A systematic review.

PLOS digital health·2025
Same author

Educating residents in spine surgery: A study of Entrustable professional activities in neurosurgery and orthopedic surgery.

PloS one·2024
Same author

Sources of Social Support and Trauma Recovery: Evidence for Bidirectional Associations from a Recently Trauma-Exposed Community Sample.

Behavioral sciences (Basel, Switzerland)·2024
Same journal

Correction: Call for Decision Support for Electrocardiographic Alarm Administration Among Neonatal Intensive Care Unit Staff: Multicenter, Cross-Sectional Survey.

Journal of medical Internet research·2026
Same journal

A Futures Framework for Clinical AI Governance: Anticipating Emerging Risks, Shifting Roles, and Regulatory Challenges.

Journal of medical Internet research·2026
Same journal

Using a Large Language Model to Support Thematic Analysis of Patient Experiences in Chronic Illness Management: Comparative Qualitative Study.

Journal of medical Internet research·2026
Same journal

Combined Internet-Based Cognitive Behavioral Therapy and Face-to-Face Physiotherapy in Primary Health Care for Chronic Widespread Pain: Randomized Controlled Trial.

Journal of medical Internet research·2026
Same journal

Operationalizing Digital Health Equity in Artificial Intelligence-Enabled Patient Decision Aids for Older Adults: Mixed Methods Study.

Journal of medical Internet research·2026
Same journal

Automated Prediction of Glasgow Coma Scale Scores From Unstructured Electronic Health Records Using Natural Language Processing: Development and Validation Study.

Journal of medical Internet research·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

31.8K

Web-based intervention programs for depression: a scoping review and evaluation.

Tian Renton1, Herman Tang, Naomi Ennis

  • 1Trauma and Neurosurgery Program, St Michael's Hospital, Toronto, ON, Canada.

Journal of Medical Internet Research
|September 25, 2014
PubMed
Summary
This summary is machine-generated.

Online depression interventions offer accessible treatment options, but many lack evidence-based support. Future programs should enhance accessibility and cater to diverse populations for improved mental health care.

Keywords:
Web-based interventionsdepressionhealth care accessinteractive treatmentmental healthtechnology

More Related Videos

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K
Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

1.1K

Related Experiment Videos

Last Updated: Apr 23, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

31.8K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K
Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
10:54

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

1.1K

Area of Science:

  • Digital mental health
  • Online interventions
  • Depression treatment

Background:

  • Millions worldwide face barriers to depression treatment, including resource scarcity, stigma, and accessibility issues.
  • Internet-delivered interventions present a viable solution to overcome these treatment barriers.

Purpose of the Study:

  • To identify available web-delivered depression programs with interactive treatment components.
  • To evaluate the content, accessibility, and usability of these programs.
  • To assess the tools, support, and research evidence supporting each program.

Main Methods:

  • A scoping review using major search engines (Google, Yahoo, Bing) and the Beacon website.
  • Independent review by two researchers to assess accessibility, usability, tools, support, and evidence.
  • Programs categorized as evidence-based if supported by at least one randomized controlled trial.

Main Results:

  • 32 interactive web-delivered depression programs were identified, showing significant variability.
  • Cognitive behavioral therapy was the predominant therapeutic approach.
  • Only 12 of the 32 programs had published evidence supporting their efficacy.

Conclusions:

  • Numerous interactive online depression interventions exist, yet many require improvement.
  • Recommendations include multilingual options, removal of registration barriers, free trials, and adaptation for special populations.
  • Enhancing user control and tailoring content to specific audiences are crucial for accessible intervention tools.