Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rosacea: disturbed defense against brain overheating.

H Brinnel1, J Friedel, M Caputa

  • 1Service de Médecine, Hôpital-Maternité, L'Arbresle, France.

Archives of Dermatological Research
|January 1, 1989
PubMed
Summary

Individuals with rosacea exhibit suppressed venous blood flow from the skin to the brain, hindering selective brain cooling during hyperthermia. This finding suggests a key mechanism in rosacea pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[150 years of Annales de dermatologie 1868-2018].

Annales de dermatologie et de venereologie·2019
Same author

[Reactive perforating collagenosis].

Annales de dermatologie et de venereologie·2012
Same author

The absorption and metabolism of a standard oral dose of levodopa in patients with Parkinsonism.

British journal of clinical pharmacology·2012
Same author

[Chronically neglected malignant skin tumours].

Annales de dermatologie et de venereologie·2012
Same author

[Annular elastolytic giant cell granuloma].

Annales de dermatologie et de venereologie·2010
Same author

[Birt-Hogg-Dubé syndrome and multiple recurrent tumors].

La Revue de medecine interne·2010

Area of Science:

  • Physiology
  • Dermatology
  • Thermoregulation

Background:

  • Rosacea is a common skin condition characterized by facial redness and inflammation.
  • Thermoregulation plays a crucial role in maintaining physiological balance.
  • Understanding impaired heat dissipation mechanisms is vital for rosacea research.

Purpose of the Study:

  • To investigate the role of selective brain cooling in individuals with rosacea.
  • To compare thermoregulatory responses between rosacea patients and healthy controls during hyperthermia.
  • To explore potential alterations in cranial venous blood flow patterns in rosacea.

Main Methods:

  • Measurements of tympanic, esophageal, forehead, and skin temperatures.
  • Forehead skin evaporation rate assessment.

Related Experiment Videos

  • Ultrasonic Doppler assessment of cranial emissary vein blood flow during normothermia and hyperthermia.
  • Inclusion of four rosacea patients and two healthy controls.

    • Main Results:

    • In rosacea patients, forehead temperature was consistently higher than in controls.
    • During hyperthermia with facial fanning, control subjects showed decreased tympanic temperature relative to esophageal temperature, indicating brain cooling.
    • Rosacea patients did not exhibit this selective brain cooling; their tympanic temperature remained higher than esophageal temperature, with no significant change in cranial venous blood flow patterns.

    Conclusions:

    • Venous blood flow from the skin to the brain appears suppressed in rosacea patients.
    • This suppression inhibits selective brain cooling during hyperthermic conditions.
    • The findings suggest a potential mechanism in the pathogenesis of rosacea and highlight a novel investigative approach.