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[Suppressor T cells against delayed type hypersensitivity to Mycobacterium intracellulare]
Nihon Ika Daigaku Zasshi
|April 1, 1989
Summary
A suppressor mechanism hinders acquired immunity against Mycobacterium intracellulare in susceptible mice. Suppressor T cells, identified by alpha Thy-1 antibody, inhibit delayed type hypersensitivity (DTH) during both induction and expression phases.
Area of Science:
- Immunology
- Microbiology
Context:
- Susceptible mouse models (C57BL/6) exhibit progressive Mycobacterium intracellulare growth.
- Inducing acquired immunity against M. intracellulare in these mice is challenging.
- Weak delayed type hypersensitivity (DTH) response observed in C57BL/6 mice suggests an existing suppressor mechanism.
Purpose:
- To investigate the presence and phase (induction vs. expression) of a suppressor mechanism in the DTH response to M. intracellulare.
- To determine if suppressor T cells are involved in inhibiting the DTH response.
Summary:
- Cell transfer experiments using spleen cells from M. intracellulare-sensitized mice demonstrated significant suppression of DTH in recipient mice.
- Suppression was observed when cells were transferred before sensitization (induction phase) and after sensitization (expression phase).
- Treatment of transferred cells with alpha Thy-1 antibody and complement abolished the suppressive activity, indicating the involvement of Thy-1 positive T cells.
Impact:
- Identifies a T cell-mediated suppressor mechanism that impedes the development of protective immunity against M. intracellulare.
- Provides insights into the complex immune regulation governing M. intracellulare infections.
- Suggests potential therapeutic targets for enhancing immune responses in susceptible individuals.