Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure
Boris Schmidtgall1, Anatol P Spork, Falk Wachowius
1University of Paderborn, Department of Chemistry, Warburger Str. 100, 33 098 Paderborn, Germany.
Chemical Communications (Cambridge, England)
|September 25, 2014
Abstract:
The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.
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