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Updated: Apr 23, 2026

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Circulating glioma biomarkers.

Johan M Kros¹, Dana M Mustafa¹, Lennard J M Dekker¹

¹Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands (J.M.K., D.M.M., P.-P.Z.); Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands (L.J.M.D., P.A.E.S.S., T.M.L.); Brain Tumor Center Rotterdam, Erasmus Medical Center, Rotterdam, The Netherlands (J.M.K., D.M.M., L.J.M.D., P.A.E.S.S., T.M.L., P.-P.Z.).

|September 26, 2014

Summary

This summary is machine-generated.

Finding reliable biomarkers in body fluids for glioma patients is crucial. Current research focuses on circulating tumor cells and nucleic acids for better treatment monitoring.

Keywords:

Omics biomarker blood cerebrospinal fluid circulating tumor cell exosome glioma nucleic acid

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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Area of Science:

Neuro-oncology
Biomarker Discovery
Clinical Diagnostics

Background:

Gliomas lack validated circulating biomarkers for treatment monitoring in clinical practice.
Circulating body fluids present an accessible source for potential glioma biomarkers.

Purpose of the Study:

To review current categories of tumor-associated circulating biomarkers in glioma patients.
To discuss the validation status and clinical utility of these biomarkers.

Main Methods:

Literature review of studies identifying circulating tumor cells, exosomes, nucleic acids, proteins, and oncometabolites in glioma patient blood and cerebrospinal fluid.

Main Results:

Numerous protein biomarkers have been reported but none meet validation criteria for clinical use.
Circulating tumor cells, exosomes, and nucleic acids show promise for future biomarker development.

Conclusions:

Validated circulating biomarkers are essential for glioma treatment standardization.
Advancements in detecting circulating tumor components may lead to clinically useful biomarkers.