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Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells
Yue Tang1, Naomi Abe, Motoko Yoshimoto
1a Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.
Bioscience, Biotechnology, and Biochemistry
|September 26, 2014
Abstract:
An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium ionophore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogen-activated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.

