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The lead program at CPRI.

H C Poon1, R Carson, F Peter

  • 1Clinical Laboratory, Children's Psychiatric Research Institute, Ontario, Canada.

Clinical Biochemistry
|June 1, 1989
PubMed
Summary
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This 11-year study of a lead (Pb) screening program revised the upper reference limit for blood lead to 0.89 mumol/L. Erythrocyte protoporphyrin (EP) levels also established a new reference limit, showing a significant correlation with blood lead.

Area of Science:

  • Environmental Health
  • Pediatric Toxicology
  • Clinical Chemistry

Background:

  • A long-term lead (Pb) screening program has been active since 1977 in London, Ontario.
  • The program simultaneously measures blood Pb and erythrocyte protoporphyrin (EP) in a vulnerable pediatric population.

Purpose of the Study:

  • To evaluate an 11-year dataset from a lead screening program.
  • To establish revised reference limits for blood lead and erythrocyte protoporphyrin.
  • To analyze correlations and demographic differences in lead exposure markers.

Main Methods:

  • Utilized a large database from an 11-year lead screening program.
  • Applied log-normal transformation for data analysis.
  • Compared blood Pb and EP levels across admission, discharge, and outpatient visits.

Related Experiment Videos

  • Analyzed demographic data (sex) and temporal trends.

    • Main Results:

    • Established a revised upper reference limit for blood Pb at 0.89 mumol/L (95% CI) based on 4188 samples.
    • Suggested an upper reference limit for EP of 1.09 mumol/L.
    • Found a significant positive correlation between annual means of blood Pb and EP (r=0.80, P<0.004).
    • No significant differences in blood Pb or EP were observed between admission, discharge, or outpatient groups.

    Conclusions:

    • The study provides updated reference values for blood lead and erythrocyte protoporphyrin in a pediatric population.
    • The findings support the continued monitoring of lead exposure in children and adolescents.
    • The established correlation highlights EP as a useful biomarker for lead exposure assessment.