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Updated: Apr 23, 2026

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Preliminary dosimetric evaluation of (166)Ho-TTHMP for human based on biodistribution data in rats
Hassan Yousefnia1, Samaneh Zolghadri1, Amir Reza Jalilian1
1Nuclear Science and Technology Research Institute (NSTRI), Tehran 14395-836, Iran.
Abstract:
In this work, the absorbed dose to each organ of human for (166)Ho-TTHMP was evaluated based on biodistribution studies in rats by a RADAR method and was compared with (166)Ho-DOTMP as the only clinically used Ho-166 bone marrow ablative agent. The highest absorbed dose for this complex is observed in red marrow with 0.922mGy/MBq. The results show that (166)Ho-TTHMP has considerable characteristics compared to (166)Ho-DOTMP and can be a good candidate for bone marrow ablation in patients with multiple myeloma.
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