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Risk of autism associated with general anesthesia during cesarean delivery: a population-based birth-cohort analysis

Li-Nien Chien1, Hsiu-Chen Lin, Yu-Hsuan Joni Shao

  • 1School of Health Care Administration, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.

Journal of Autism and Developmental Disorders
|September 27, 2014
PubMed

The rates of Cesarean delivery (C-section) have risen to >30% in numerous countries. Increased risk of autism has been shown in neonates delivered by C-section. This study examined the incidence of autism in neonates delivered vaginally, by C-section with regional anesthesia (RA), and by C-section with general anesthesia (GA) to evaluate the risk of autism associated with C-section and obstetric anesthesia. During a mean follow-up of 4.3 years, the incidence of autism was higher in neonates delivered by C-section with GA than in neonates delivered vaginally, with an adjusted risk of 1.52 (95% confidence interval 1.18-1.94). However, the adjusted risk of autism in neonates delivered by C-section with RA and in neonates delivered vaginally was nonsignificantly different.

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