[The Z-form of bacteriophage lambda DNA, modified in situ]

Using the methods of chemical modification, restriction analysis and immune-electron microscopy it has been shown that the definite regions of the bacteriophage lambda DNA contain unpaired bases in situ. The distribution map of such sites along the genome has been constructed. The correlation of the in situ modification and the reaction with anti-Z-DNA antibodies is shown for the 44972 bp site of bacteriophage DNA. The possibility of the existence of Z-form DNA in situ is discussed.