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Mice lacking chromogranins exhibit increased aggressive and depression-like behaviour.
Daniel Pereda1, Marta R Pardo1, Yezer Morales1
1Pharmacology Unit, Medical School, University of La Laguna, Tenerife, Spain.
Behavioural Brain Research
|September 27, 2014
Summary
Chromogranins A and B influence insulin sensitivity and stress response. Lacking these proteins in mice altered metabolic profiles and promoted aggressive behaviors, revealing new physiological roles.
Area of Science:
- Neuroscience
- Endocrinology
- Genetics
Background:
- Chromogranins A and B are key proteins in large dense core vesicles, serving as precursors for bioactive peptides.
- These peptides have been implicated in vascular and neurological conditions.
Purpose of the Study:
- To investigate the physiological roles of chromogranins A and B.
- To characterize metabolic, cardiovascular, and behavioral functions associated with chromogranin deficiency.
Main Methods:
- Utilized three distinct genetic mutant mouse models lacking chromogranin A, chromogranin B, or both.
- Conducted comprehensive phenotyping including metabolic, cardiovascular, and behavioral assessments on over 2800 mice.
Main Results:
- Mice lacking any chromogranin showed age-dependent insulin hypersensitivity.
- Absence of both chromogranins led to a progressive loss of stress response and increased aggressive behaviors (barbering).
- Chromogranin B deficiency resulted in depressive-like and aggressive phenotypes, with reduced exploratory activity.
Conclusions:
- Chromogranins play significant roles in regulating aggressive behavior and metabolic profiles.
- Peptides derived from chromogranins contribute to these physiological functions beyond their known roles in the secretory pathway.
