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Cellular responses to egg-oil (charismon©).

Jürgen Bereiter-Hahn1, August Bernd2, Heike Beschmann2

  • 1Kinematic Cell Research Group, Institute for Cell Biology and Neurosciences, Goethe University Frankfurt am Main, Germany. hahn@bio.uni-frankfurt.de.

Acta Medica (Hradec Kralove)
|September 27, 2014
PubMed
Summary

Egg-oil demonstrates wound healing benefits by reducing inflammation and reactive oxygen species (ROS). This study investigated its effects on skin cells, immune cells, and UV-damaged skin models, revealing its potential in skin repair and anti-aging.

Keywords:
Charismon©HUVECHaCaTHuman skin modelInflammationInterleukinsPBMLReactive oxygen speciesRespirationWound healing

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Area of Science:

  • Dermatology
  • Cell Biology
  • Immunology

Background:

  • Egg-oil (Charismon©) is recognized for wound healing, skin irritation relief, and antibacterial properties.
  • The underlying physiological mechanisms require detailed investigation.
  • Understanding its cellular actions is crucial for therapeutic applications.

Purpose of the Study:

  • To elucidate the physiological basis of egg-oil's beneficial effects on skin.
  • To investigate egg-oil's influence on cellular processes including migration, proliferation, and inflammatory responses.
  • To assess egg-oil's protective and recovery effects on UV-irradiated human skin models.

Main Methods:

  • Utilized HaCaT cells (immortalized human keratinocytes) to study IL-8 production and migration.
  • Employed human umbilical vein endothelial cells (HUVEC) and HaCaT cells to assess respiration, mitochondrial membrane potential, ROS production, and proliferation.
  • Investigated peripheral blood mononuclear lymphocytes (PBML) for cytokine and interleukin production and a full-thickness human skin model (FTSM) for UV-induced damage recovery.

Main Results:

  • Egg-oil stimulated IL-8 production in HaCaT cells but reduced interleukins (IL-2, IL-6, IL-10, IFN-γ) and TNF-α in activated PBMLs.
  • Initially enhanced, then reduced reactive oxygen species (ROS) production post-H2O2 stimulation; activated respiration via mitochondrial respiratory chain uncoupling; reduced HaCaT and HUVEC proliferation.
  • Significantly supported recovery of human epidermis cells in FTSM after UV irradiation.

Conclusions:

  • Egg-oil exerts its beneficial effects by mitigating inflammatory processes and reducing reactive oxygen species (ROS) production.
  • These mechanisms are vital for both cellular aging and the healing of chronic wounds.
  • The findings support egg-oil as a therapeutic agent for skin conditions involving inflammation and oxidative stress.