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Updated: Apr 23, 2026

Detection of Bacteria Using Fluorogenic DNAzymes
Published on: May 28, 2012
A reversible and reusable selective chemosensor for fluoride detection using a phenolic OH-containing BODIPY dye by
Lingyun Wang1, Guipo Fang, Derong Cao
1School of Chemistry and Chemical Engineering, South China University of Technology, 510640, Guangzhou, China, lingyun@scut.edu.cn.
Abstract:
A novel BODIPY-based probe 1 was designed and synthesized as a selective fluorescent and colorimetric chemosensor for fluoride. The spectral responses of 1 to fluoride in acetonitrile were studied: an approximately 118 nm red shift in absorption and 'turn-off' emission response was observed. The striking pink to indigo change in ambient light was thought to be due to the deprotonation of the phenol moiety by way of O-H · · · F hydrogen bonding interactions. Interestingly, when the nonfluorescent 1-F(-) solution treated with trifluoroacetic acid (TFA) resulted in color change from indigo to pink and a significant enhancement of fluorescence intensity (10-fold). Furthermore, the reversibility and reusability of probe 1 for the detection of F(-) ion was tested for four cycles indicating the probe 1 could be used in reversible manner.
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