Stress-induced changes in the liver of rats with different resistance to stress

We compared changes in the liver structure in stress-resistant and stress-sensitive rats under conditions of chronic stress exposure. The number of degenerative cells, specific area of degenerative part of hepatocyte cytoplasm, and specific area of intralobular sinusoidal capillaries increased in animals of both groups. These parameters were significantly higher in stresss-ensitive rats. Reparative processes that manifested in increased in number of binucleated hepatocytes and number of nucleoli in nuclei were observed in the liver parenchyma. These changes were more pronounced in animals with high resistance to stress. Nucleus hypertrophy was also found in these rats.