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Antithrombotic activity of a new benzimidazole derivative in the thrombosis model in mice
A V Smirnov1, A F Kucheryavenko, A A Spasov
1Department for Pathological Anatomy, Volgograd State Medical University, Volgograd, Russia.
Bulletin of Experimental Biology and Medicine
|September 27, 2014
Abstract:
Antithrombotic activity of a new benzimidazole derivative RU-891, characterized by antiaggregant activity, vs. reference drug acetylsalicylic acid was studied on the epinephrinecollagen thrombosis model in mice. Antithrombotic activity of RU-891 3-fold surpassed that of the reference drug. Histological studies showed that RU-891 significantly reduced the relative and mean areas of thrombi in sections of mouse lungs in comparison with the control.

