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Updated: Apr 23, 2026
Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
Published on: June 17, 2016
Characteristics of mesenchymal stromal cells isolated from patients with breast cancer
A A Pinevich1, M P Samoilovich, O A Shashkova
1Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia, agniapinevich@gmail.com.
Abstract:
Mesenchymal stromal cells were isolated from the adipose tissue obtained during surgery for breast cancer and cultured under conditions of normal or low oxygen concentrations. In patients that had received a course of radiation and polychemotherapy prior to surgery, the proliferative potential of mesenchymal stromal cells was irreversibly disturbed. In patients receiving no therapy prior to surgery, the morphological, growth, phenotypic, and differentiation characteristics of mesenchymal stromal cells did not differ from the corresponding parameters of mesenchymal stromal cells from healthy donors. Culturing under hypoxic conditions increased adipogenic differentiation potencies of mesenchymal stromal cells from donors and patients.
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