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Related Experiment Video

Updated: Apr 23, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

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Percent Mammographic Density and Dense Area as Risk Factors for Breast Cancer.

C Rauh1, C C Hack1, L Häberle1

  • 1Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen.

Geburtshilfe Und Frauenheilkunde
|September 27, 2014
PubMed
Summary

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Adding absolute dense area (DA) to mammographic density (PMD) assessments improves breast cancer risk prediction. This imaging metric, alongside traditional factors, offers a more comprehensive risk evaluation for women.

Area of Science:

  • Radiology and Oncological Imaging
  • Biostatistics and Epidemiology

Background:

  • Mammographic density (PMD) is a known breast cancer risk factor.
  • Computer-assisted methods provide PMD and absolute dense area (DA) measurements.
  • The predictive value of DA for breast cancer risk requires further investigation.

Purpose of the Study:

  • To evaluate the predictive value of absolute dense area (DA) for breast cancer risk.
  • To determine if DA improves breast cancer risk prediction models beyond established factors and PMD.

Main Methods:

  • A hospital-based case-control study involving 561 invasive breast cancer patients and 376 controls.
  • Analysis of mammographic density (PMD) and absolute dense area (DA).
  • Comparison of prediction models including common risk factors (BMI, HRT, menopause, marital status) with and without DA.
Keywords:
breast cancermammographic densityrisk

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Main Results:

  • PMD and DA were highly correlated; PMD showed a stronger correlation with BMI.
  • Women in the highest PMD quartile had an odds ratio (OR) of 2.12 for breast cancer.
  • Including DA in prediction models improved breast cancer risk assessment.

Conclusions:

  • Absolute dense area (DA) can enhance breast cancer risk prediction when combined with PMD and other risk factors.
  • DA is readily available from computer-assisted PMD assessments.
  • DA warrants consideration as an additional breast cancer risk factor derived from mammography.