Microalbuminuria associated with a rise in blood pressure in non-insulin-dependent diabetes
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R Kikkawa1, M Haneda, M Togawa
1Third Department of Medicine, Shiga University of Medical Science, Otsu, Japan.
Abstract:
The association between microalbuminuria and systemic blood pressure was investigated in 80 nonproteinuric subjects with non-insulin-dependent diabetes. Seventeen of 80 diabetics had urinary albumin excretion rates (AER) over 20 micrograms/min and were defined as microalbuminuric. The microalbuminuric diabetics showed a higher incidence of proliferative retinopathy and neuropathy than the normoalbuminurics. Moreover, the former group had significantly higher values of systolic blood pressure compared to the latter, although the creatinine clearance was not significantly different between the two groups. These results suggest that microalbuminuria is strongly associated with a rise of systemic blood pressure in non-insulin-dependent diabetics.
Insights
Microalbuminuria, an early sign of kidney damage, is linked to higher blood pressure in diabetics. This study highlights the connection between elevated urinary albumin excretion rates and increased systolic blood pressure in non-insulin-dependent diabetes mellitus.
Area of Science:
- Nephrology
- Endocrinology
- Diabetology
Background:
- Microalbuminuria is an early indicator of diabetic kidney disease.
- Non-insulin-dependent diabetes mellitus (NIDDM) affects a significant population globally.
- Systemic blood pressure is a critical factor in diabetic complications.
Purpose of the Study:
- To investigate the association between microalbuminuria and systemic blood pressure in nonproteinuric NIDDM subjects.
- To determine if microalbuminuria correlates with other diabetic microvascular complications.
Main Methods:
- Studied 80 nonproteinuric subjects with NIDDM.
- Categorized subjects into microalbuminuric (urinary albumin excretion rate [AER] > 20 µg/min) and normoalbuminuric groups.
- Compared systolic blood pressure, retinopathy, neuropathy, and creatinine clearance between groups.
Main Results:
- 17 out of 80 NIDDM subjects were classified as microalbuminuric.
- Microalbuminuric diabetics exhibited a higher incidence of proliferative retinopathy and neuropathy.
- Systolic blood pressure was significantly higher in microalbuminuric individuals compared to normoalbuminuric individuals.
- Creatinine clearance did not significantly differ between the groups.
Conclusions:
- Microalbuminuria is strongly associated with elevated systemic blood pressure in NIDDM.
- Microalbuminuria may serve as an early marker for increased cardiovascular risk in diabetics.
- Early detection and management of microalbuminuria are crucial in NIDDM patients.