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Sodium 3D COncentration MApping (COMA 3D) using (23)Na and proton MRI.

Milton L Truong1, Michael G Harrington2, Victor D Schepkin3

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Summary

This study presents an automated MATLAB toolbox for converting 3D sodium MRI signals into millimolar concentration maps. This enables non-invasive, quantitative measurement of in vivo sodium concentration changes in rat brains, particularly for migraine research.

Keywords:
(23)Na21.1T3D MRIConcentrationImagingMATLABNMRSodium

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Area of Science:

  • Biomedical Imaging
  • Neuroscience
  • Medical Physics

Background:

  • Sodium-3D MRI signals require conversion to quantitative concentration data for functional analysis.
  • Co-registration of sodium concentration maps with proton images is crucial for anatomical correlation.

Purpose of the Study:

  • To develop and validate an open-source, automated MATLAB toolbox for processing 3D sodium MRI data.
  • To enable non-invasive, quantitative measurement of in vivo sodium concentration changes.
  • To apply the toolbox to study functional sodium changes in migraine-like conditions in rats.

Main Methods:

  • Utilized an automated MATLAB toolbox to convert 3D sodium MRI signals to millimolar concentration changes.
  • Generated 3D sodium concentration maps with high spatial resolution (0.8×0.8×0.8 mm³).
  • Acquired 3D sodium MRI brain images from live rats at 21.1T.

Main Results:

  • Successfully generated nearly 5000/h concentration maps on a personal computer.
  • Produced quantitative in vivo sodium concentration maps for normal rat brains.
  • Demonstrated the utility of the maps in assessing functional responses to migraine-like conditions.

Conclusions:

  • The developed MATLAB toolbox provides automated image analysis for 3D sodium MRI data.
  • This method allows for non-invasive quantitative measurement of in vivo sodium concentration.
  • The approach is applicable to studying sodium-associated changes in various conditions like migraine and cancer.