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Microparticle-associated tissue factor activity in patients with acute unprovoked deep vein thrombosis and during the

Johannes Thaler1, Renate Koppensteiner2, Ingrid Pabinger1

  • 1Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Austria.

Thrombosis Research
|September 29, 2014
PubMed
Abstract

Insights

Tissue factor-bearing microparticles (TF-MPs) are not elevated in patients with unprovoked deep vein thrombosis (DVT). TF-MP activity remains low and unchanged throughout the disease course, suggesting they do not drive DVT pathogenesis.

Area of Science:

  • Hematology
  • Vascular Biology
  • Thrombosis Research

Background:

  • Tissue factor (TF) initiates blood coagulation in vivo.
  • Microparticles (MPs) are procoagulant vesicles; TF-bearing MPs are implicated in prothrombotic states.
  • Elevated TF-bearing MPs may contribute to unprovoked deep vein thrombosis (DVT) pathogenesis.

Purpose of the Study:

  • To quantify microparticle-tissue factor (MP-TF) activity in patients with unprovoked DVT.
  • To assess MP-TF activity at diagnosis and over a one-year follow-up period.
  • To investigate the role of MP-TF activity in DVT pathogenesis.

Main Methods:

  • 41 patients with acute, unprovoked lower limb DVT were enrolled.
  • MP-TF activity was measured at diagnosis and at 1, 3, 6, and 12 months.
  • 10 healthy individuals served as controls.

Main Results:

  • Median MP-TF activity was similar in DVT patients (0.06 pg/mL) and controls (0.18 pg/mL) (p=0.35).
  • MP-TF activity showed no significant changes during the one-year follow-up.
  • No significant differences in MP-TF activity were observed based on DVT location or residual thrombosis.

Conclusions:

  • MP-TF activity is low in acute unprovoked DVT and stable over time.
  • The findings do not support a significant role for TF-bearing MPs in the pathogenesis of unprovoked DVT.
Keywords:
Deep vein thrombosisLower limbMicroparticlesTissue factorVenous thromboembolism

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