Related Experiment Video
Updated: Apr 23, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
Published on: November 22, 2019
Epithelial plasticity in prostate cancer: principles and clinical perspectives
Rajdeep Das1, Philip A Gregory2, Brett G Hollier3
1Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, The University of Adelaide, South Australia, Australia; Freemasons Foundation Centre for Men's Health, The University of Adelaide, South Australia, Australia; Discipline of Medicine, The University of Adelaide, South Australia, Australia.
Abstract:
Over the past decade, the capacity of cancer cells to oscillate between epithelial and mesenchymal phenotypes, termed epithelial plasticity (EP), has been demonstrated to play a critical role in metastasis. This phenomenon may be particularly important for prostate cancer (PC) progression, since recent studies have revealed interplay between EP and signaling by the androgen receptor (AR) oncoprotein. Moreover, EP appears to play a role in dictating the response to therapies for metastatic PC. This review will evaluate preclinical and clinical evidence for the relevance of EP in PC progression and consider the potential of targeting and measuring EP as a means to treat and manage lethal forms of the disease.
Related Concept Videos
Cellular Adaptation IV: Dysplasia and Metaplasia
Cellular Adaptation III: Hyperplasia

