Enhanced cell adhesion to the dimpled surfaces of golf-ball-shaped microparticles

Engineering surface morphology as in honeycomb-structured planar films is of great importance for providing new potential application and improved performance in biomedical fields. We demonstrate potential new applications for the uniform biocompatible golf-ball-shaped microparticles that resembles 3D feature of honeycomb-structured film. Dimple size controllable golf-ball-shaped microparticles were fabricated by microfluidic device. Surface dimples not only can act as picoliter beaker but also enhance cell adhesion without any chemical modification of the surface.