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Relationship between Helicobacter pylori infection and psoriasis
Maryam Azizzadeh, Zahra Vafaei Nejad, Raheb Ghorbani
1Daryoush Pahlevan, Research Center for Social Determinants of Health, Semnan, Iran, dpahlevan@yahoo.com.
Annals of Saudi Medicine
|October 1, 2014
Summary
This study found no significant link between Helicobacter pylori infection and psoriasis. Further research is needed to explore if H. pylori infection causes or worsens psoriasis symptoms.
Area of Science:
- Dermatology
- Gastroenterology
- Immunology
Background:
- Psoriasis is a chronic inflammatory skin condition with unknown etiology.
- Helicobacter pylori (H. pylori) is a bacterium linked to gastritis.
- Emerging evidence suggests a potential role for H. pylori in psoriasis development.
Purpose of the Study:
- To investigate the association between H. pylori seropositivity and psoriasis vulgaris.
- To determine if H. pylori infection levels correlate with psoriasis severity.
Main Methods:
- A case-control study involving 61 psoriasis patients and 61 healthy controls.
- H. pylori infection was assessed via serology, detecting immunoglobulin G (IgG) anti-H. pylori antibodies using ELISA.
- Participants were recruited from Fatemiye Hospital, Semnan, Iran.
Main Results:
- H. pylori seropositivity was observed in 16.4% of psoriasis patients and 13% of controls.
- The average serum IgG anti-H. pylori levels were 17.3 IU/ML in patients and 16.1 IU/ML in controls.
- No statistically significant difference in IgG anti-H. pylori levels was found between the groups (P=.302).
Conclusions:
- The study found no significant relationship between psoriasis and IgG anti-H. pylori serum levels.
- Psoriasis severity did not correlate significantly with IgG anti-H. pylori serum levels.
- Further research is recommended to clarify the potential role of H. pylori infection in causing or exacerbating psoriasis.
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