Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunological tolerance: new approaches using transgenic mice.

J F Miller, G Morahan, J Allison

    Immunology Today
    |February 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Spot size measurement of a deuterium-tritium dense plasma focus using neutron radiography.

    The Review of scientific instruments·2024
    Same author

    Immune biomarker evaluation of sequential tyrosine kinase inhibitor and nivolumab monotherapies in renal cell carcinoma: the phase I TRIBE trial.

    Immuno-oncology technology·2024
    Same author

    Photon quantum entanglement in the MeV regime and its application in PET imaging.

    Nature communications·2021
    Same author

    Developing a comprehensive database with sensitive health information: A profile of people living with HIV in Newfoundland and Labrador, Canada.

    International journal of population data science·2020
    Same author

    Feasibility of perioperative volatile organic compound breath testing for prediction of paralytic ileus following laparoscopic colorectal resection.

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2019
    Same author

    2D versus 3D laparoscopic total mesorectal excision: a developmental multicentre randomised controlled trial.

    Surgical endoscopy·2019
    Same journal

    Foreword.

    Immunology today·2020
    Same journal

    The origin and significance of anti-DNA antibodies.

    Immunology today·2014
    Same journal

    Mutations of class II MHC molecules.

    Immunology today·2014
    Same journal

    Antigen processing at the molecular level.

    Immunology today·2014
    Same journal

    Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

    Immunology today·2014
    Same journal

    Are MHC class II-restricted cytotoxic T lymphocytes important?

    Immunology today·2014
    See all related articles

    Transgenic technology enables introducing foreign genes into animals to study self-tolerance. This approach synthesizes antigens as self-molecules, aiding research into acquired immunological tolerance mechanisms.

    Area of Science:

    • Immunology
    • Genetics
    • Transgenic Technology

    Background:

    • Acquired immunological tolerance is crucial for preventing autoimmune diseases.
    • Understanding self-tolerance mechanisms is a key challenge in immunology.
    • Transgenic animal models offer novel ways to study immune responses.

    Purpose of the Study:

    • To review the application of transgenic technology in investigating acquired immunological tolerance.
    • To explore how directing antigen expression influences immune tolerance.
    • To discuss the potential of transgenic models for understanding self-recognition by the immune system.

    Main Methods:

    • Introduction of foreign antigen genes into the animal germline.
    • Utilizing specific promoters to direct antigen expression to particular tissues.

    Related Experiment Videos

  • Synthesis of foreign antigens as authentic self-molecules within the animal.

    • Main Results:

    • Transgenic animals can express foreign antigens as self-components.
    • Tissue-specific expression of antigens can be precisely controlled.
    • This model facilitates the study of tolerance induction to self-like molecules.

    Conclusions:

    • Transgenic technology provides a powerful tool for dissecting the mechanisms of acquired immunological tolerance.
    • This approach allows for the investigation of immune responses to self-antigens in a controlled manner.
    • Further research using these models can advance our understanding of autoimmunity and immune regulation.