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Dermatoses in metal workers. (II). Allergic contact dermatitis
E M de Boer1, W G van Ketel, D P Bruynzeel
1Department of Occupational Dermatology, Free University Academic Hospital, Amsterdam.
Contact Dermatitis
|April 1, 1989
Summary
Metalworking fluid (MWF) exposure can cause contact sensitization. This study found 2.8% of metalworkers were sensitized, primarily to biocides and corrosion inhibitors in MWF.
Area of Science:
- Occupational Health
- Dermatology
- Toxicology
Background:
- Metalworking fluids (MWF) are widely used in industrial settings.
- Previous research has highlighted irritant contact dermatitis associated with MWF exposure.
- The role of specific MWF components in causing allergic contact dermatitis requires further investigation.
Purpose of the Study:
- To determine the prevalence of contact sensitization to metalworking fluids (MWF) in a cohort of metalworkers.
- To identify specific MWF components responsible for allergic contact sensitization.
- To discuss challenges in interpreting patch test results and propose preventive measures.
Main Methods:
- An epidemiological study involving 286 metalworkers exposed to MWF.
- Patch testing performed on 40 employees with dermatitis using routine series, MWF components, and preservatives.
- Analysis of sensitization prevalence and identification of allergens.
Main Results:
- Contact sensitization was identified in 8 workers (2.8% prevalence).
- Four sensitized workers were allergic to biocides and/or corrosion inhibitors present in MWF.
- Difficulties in assessing the clinical relevance of positive patch test reactions were noted.
Conclusions:
- Biocides and corrosion inhibitors in MWF are significant causes of contact sensitization in metalworkers.
- Careful interpretation of patch test results is crucial for accurate diagnosis.
- Implementing measures to reduce preservative induction of sensitization in water-based MWF is recommended.