Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis.

Annals of clinical and translational neurology·2026
Same author

German Society of Nuclear Medicine procedure guideline for brain perfusion SPECT using 99mTc-labelled radiopharmaceuticals (09/2025).

Nuklearmedizin. Nuclear medicine·2026
Same author

FDG PET Hybrid Imaging.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same author

Updated Procedure Guideline of the German Society of Nuclear Medicine for Amyloid Brain PET Imaging 3.0.

Nuklearmedizin. Nuclear medicine·2026
Same author

Radiopharmaceutical Therapy Meets Radiobiology: Implications for Trial Design and DNA Repair Inhibitor Combinations.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

<sup>90</sup>Y-FAPI-46 Radiopharmaceutical Therapy in Sarcoma and Other Solid Tumors: An Updated Cohort Analysis.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

Related Experiment Video

Updated: Apr 23, 2026

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

9.3K

CT-based attenuation correction in I-123-ioflupane SPECT.

Catharina Lange1, Anita Seese2, Sarah Schwarzenböck3

  • 1Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Plos One
|October 1, 2014
PubMed
Summary

CT-based attenuation correction (AC) for dopamine transporter SPECT showed negligible impact on image interpretation compared to the Chang method. CT-based AC is not recommended for routine clinical use due to minimal benefits and added radiation exposure.

More Related Videos

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.1K
Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
09:00

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Published on: August 18, 2016

7.1K

Related Experiment Videos

Last Updated: Apr 23, 2026

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

9.3K
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.1K
Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
09:00

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Published on: August 18, 2016

7.1K

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Neuroimaging

Background:

  • Attenuation correction (AC) in brain single-photon emission computed tomography (SPECT) is crucial for accurate image analysis.
  • Low-dose computed tomography (CT) offers a potential alternative to traditional methods like the Chang method for AC.
  • Accurate AC can enhance both semi-quantitative and visual assessments in SPECT imaging.

Purpose of the Study:

  • To evaluate the efficacy of CT-based AC compared to the Chang method for I-123-ioflupane dopamine transporter SPECT.
  • To determine the impact of CT-based AC on semi-quantitative analysis (specific-to-background ratios) and visual interpretation of brain SPECT images.

Main Methods:

  • Retrospective analysis of 62 patients undergoing I-123-ioflupane SPECT with low-dose CT.
  • Reconstruction of SPECT images with no AC, Chang AC, and CT-based AC.
  • Semi-quantitative analysis using automated region of interest (ROI) placement and receiver-operator characteristic (ROC) analysis for diagnostic power.
  • Independent visual interpretation of normalized SPECT images by two raters.

Main Results:

  • CT-based AC yielded specific-to-background ratios (SBRs) intermediate between no AC and Chang AC.
  • The maximum area under the ROC curve for putamen SBR showed negligible differences across all AC methods (0.924-0.938).
  • Diagnostic accuracy in visual interpretation was not significantly affected by the type of AC used.

Conclusions:

  • The impact of CT-based AC versus Chang AC on I-123-ioflupane SPECT interpretation is clinically negligible.
  • CT-based AC is not recommended for routine clinical practice in this context.
  • The additional radiation exposure from CT-based AC outweighs its minimal benefits for this specific application.