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Updated: Apr 23, 2026

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
Published on: February 15, 2021
Large-scale brain systems and subcortical relationships: the vertically organized brain
Leonard F Koziol1, Lauren A Barker, Arthur W Joyce
1a Private Practice, Clinical Neuropsychology , Arlington Heights , Illinois.
Abstract:
This article reviews the vertical organization of the brain. The cortico-basal ganglia and the cerebro-cerebellar circuitry systems are described as fundamental to cognitive and behavioral control. The basal ganglia anticipate and guide implicitly learned behaviors on the basis of experienced reward outcomes. The cerebellar-cortical network anticipates sensorimotor outcomes, allowing behaviors to be adapted across changing settings and across contexts. These vertically organized systems, operating together, represent the underpinning of cognitive control. The medial temporal lobe system, and its development, is also reviewed in order to better understand how brain systems interact for both implicit and explicit cognitive control.
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