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Related Concept Videos

Hydrogen Bonds01:04

Hydrogen Bonds

11.8K
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
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Hydrogen Bonds00:26

Hydrogen Bonds

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Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
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Intermolecular Forces03:13

Intermolecular Forces

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Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
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Intermolecular Forces03:13

Intermolecular Forces

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Intermolecular vs Intramolecular Forces03:00

Intermolecular vs Intramolecular Forces

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Intermolecular forces (IMF) are electrostatic attractions arising from charge-charge interactions between molecules. The strength of the intermolecular force is influenced by the distance of separation between molecules. The forces significantly affect the interactions in solids and liquids, where the molecules are close together. In gases, IMFs become important only under high-pressure conditions (due to the proximity of gas molecules). Intermolecular forces dictate the physical properties of...
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Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

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sp3d and sp3d 2 Hybridization
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Related Experiment Video

Updated: Apr 23, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
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From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding

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Special issue: intramolecular hydrogen bonding.

Ronald K Castellano1

  • 1Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL 32611-7200, USA. castellano@chem.ufl.edu.

Molecules (Basel, Switzerland)
|October 1, 2014
PubMed
Summary
This summary is machine-generated.

Intramolecular hydrogen bonds are vital for molecular structure and function across biology and chemistry. This collection highlights their diverse roles and advanced characterization methods.

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Area of Science:

  • Chemistry
  • Biochemistry
  • Materials Science

Background:

  • Intramolecular hydrogen bonds significantly influence molecular structure and function.
  • These interactions are crucial in both biological systems and synthetic molecules.

Discussion:

  • This special issue explores the impact of intramolecular hydrogen bonds on biologically active molecules and synthetic systems.
  • It examines their role in biological mechanisms and the conformational changes of functional synthetic molecules.

Key Insights:

  • Eight contributions demonstrate the broad significance of intramolecular hydrogen bonds across disciplines.
  • The studies cover various structural contexts and environments where these bonds are present.

Outlook:

  • State-of-the-art experimental and theoretical methods are presented for characterizing intramolecular hydrogen bonds.
  • These methods provide critical data on bond strengths, geometries, and spectroscopic signatures in different phases.