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Non-Canonical, Strongly Selective Protein Disulfide Isomerases as Anticancer Therapeutic Targets

Mary E Law1, Zaafir M Dulloo2, Brian Hardy1

  • 1Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL 32610, USA.

Biomolecules
|August 28, 2025
PubMed
Summary

Non-canonical Protein Disulfide Isomerases (PDIs), including ERp44, AGR2, and AGR3, are crucial for cancer cell survival. Inhibitors targeting these non-canonical PDIs show promise as novel anticancer therapeutics.

Keywords:
AGR2AGR3ERp44PDIA1protein disulfide isomerases

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