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Naproxen-induced bullous photodermatitis.

J K Rivers1, R S Barnetson

  • 1University of Sydney, Department of Surgery, Royal Prince Alfred Hospital, Camperdown, NSW.

The Medical Journal of Australia
|August 7, 1989
PubMed
Summary
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Naproxen can cause a blistering skin condition resembling porphyria, known as bullous photodermatitis. Symptoms resolved after discontinuing naproxen, highlighting a rare adverse drug reaction.

Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations.
  • Drug-induced dermatoses can mimic various skin conditions, complicating diagnosis and management.
  • Bullous photodermatitis, or pseudoporphyria, is a rare adverse reaction to certain medications.

Observation:

  • A 37-year-old woman with SLE developed bullous lesions on sun-exposed areas.
  • Clinical and histological findings resembled porphyria cutanea tarda.
  • No underlying hematological abnormalities indicative of PCT were identified.

Findings:

  • The patient's bullous photodermatitis was directly linked to naproxen use.
  • Lesions showed significant improvement and remission upon discontinuation of naproxen.

Related Experiment Videos

  • This represents a rare case of naproxen-induced pseudoporphyria.

    • Implications:

    • Highlights the importance of considering drug-induced reactions in dermatological presentations.
    • Suggests naproxen as a potential trigger for bullous photodermatitis in susceptible individuals.
    • Underscores the need for vigilance regarding NSAID adverse effects in patients with autoimmune conditions.