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Quantifying nicotine's value-enhancement effect using a behavioral economic approach.

Rachel N Cassidy1, Jesse Dallery

  • 1Brown University.

Journal of the Experimental Analysis of Behavior
|October 2, 2014
PubMed
Summary
This summary is machine-generated.

Nicotine enhances the perceived value of conditioned reinforcers, potentially explaining its addictive properties. This study used behavioral economics to measure nicotine

Keywords:
behavioral economicsbehavioral pharmacologyconditioned reinforcementnicotinerat

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Area of Science:

  • Neuroscience
  • Behavioral Economics
  • Psychopharmacology

Background:

  • Nicotine's abuse potential is partly linked to its ability to increase the reinforcing value of stimuli.
  • Understanding how nicotine affects the subjective value of rewards is crucial for addiction research.

Purpose of the Study:

  • To quantify the effect of nicotine on the value of conditioned reinforcers using a behavioral economic approach.
  • To investigate nicotine's impact on demand for conditioned reinforcers.

Main Methods:

  • A modified observing response procedure was used with Long-Evans rats.
  • Rats lever-pressed for food or to observe stimuli predicting food availability (conditioned reinforcers).
  • Demand curves for conditioned reinforcers were generated and analyzed using an exponential demand equation after nicotine administration (0.3 mg/kg).

Main Results:

  • Nicotine administration significantly increased the value of conditioned reinforcers, as indicated by the demand curve analysis.
  • Nicotine also increased responding on the primary food-seeking lever.

Conclusions:

  • Nicotine demonstrably increases the value of conditioned reinforcers under specific experimental conditions.
  • The employed behavioral economic procedure offers a novel method for assessing demand for conditioned reinforcers.