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Updated: Apr 23, 2026

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
Published on: July 17, 2020
[Phosphate disorders: hyperphosphatemia or pseudohyperphosphatemia?]
Nicole Aeberhard1, Christof Schild1, Nicolas Rodondi1
1Universitätsklinik für Allgemeine Innere Medizin, Inselspital Bern; Universitätsinstitut für klinische Chemie, Inselspital Bern.
Abstract:
We report the case of a 79 year old woman presenting with progressive confusion and drowsiness. Renal insufficiency with hyperkalemia as well as hypercalcemia and severe hyperphosphatemia were diagnosed. Renal insufficiency improved with treatment. However, hyperphosphatemia persisted without apparent explanation. We discuss possible causes of hyper- and pseudohyperphosphatemia. Specifically, phosphate analysis may be disturbed by the paraproteins in patients with multiple myeloma, resulting in pseudohyperphosphatemia. We review the standard laboratory phosphate measurement and the mechanisms of interference with paraproteins.
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