Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

359
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
359
Factors Affecting Activity Coefficient01:17

Factors Affecting Activity Coefficient

1.6K
The extended Debye-Hückel equation indicates that the activity coefficient of an ion in an aqueous solution at 25°C depends on three partially interdependent properties: the ionic strength of the solution, the charge of the ion, and the ion size. 
The activity coefficient value for an ion is close to one when the solution has almost zero ionic strength, i.e., when the solution shows close to ideal behavior. As the ionic strength of the solution increases from 0 to 0.1 mol/L, a...
1.6K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

1.5K
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Comparison of Measurements and Calculations of the Effects of Scattered Radiation on Dosimeter Calibration in a Calibration Range.

Health physics·2018
Same author

Evaluation of the effects of scattered radiation on dosimeter calibration in a calibration range.

Health physics·2012
Same author

Evaluation of scattered radiation in a calibration range using exposure rate energy spectra.

Health physics·2011
Same author

Evaluation of the shadow shield technique for the measurement of scattered radiation.

Health physics·2011
Same author

Molecular targeting and treatment of an epidermal growth factor receptor-positive glioma using boronated cetuximab.

Clinical cancer research : an official journal of the American Association for Cancer Research·2007
Same author

Boron neutron capture therapy of cancer: current status and future prospects.

Clinical cancer research : an official journal of the American Association for Cancer Research·2005
Same journal

Assessment of Health Risks of Adults and Children Due to Consumption of Uranium in Groundwater from Chengalpattu District, Tamil Nadu, India.

Health physics·2026
Same journal

Specialized Radiological Assets for Navigable Two-dimensional and Three-dimensional Virtual and Augmented Reality.

Health physics·2026
Same journal

DoseBusters: A Fully Immersive Virtual Reality Game for Radiation Protection and Detection.

Health physics·2026
Same journal

Radioactivity in Bottled Drinking Water from Greater Dhaka City and Concomitant Ingestion Doses to Consumers.

Health physics·2026
Same journal

Assessment of Radiation Dose and Protection Practices in Neonatal Radiography in NICUs.

Health physics·2026
Same journal

Fatty Acid Binding Proteins for Improved Prediction and Monitoring of Radiation- induced Gastrointestinal Injury.

Health physics·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources
12:47

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

Published on: January 22, 2018

9.0K

Calculating an unknown source activity using modeled and experimental results.

Matthew S Rowan1, Thomas E Blue, Kevin Herminghuysen

  • 1*The Ohio State University, Nuclear Engineering Program, 201 W. 19th Avenue, Columbus, OH 43210; †The Ohio State University Nuclear Reactor Laboratory, 1298 Kinnear Road, Columbus, OH 43212.

Health Physics
|October 2, 2014
PubMed
Summary
This summary is machine-generated.

This study introduces a novel method for calculating unknown source activity using experimental measurements and MCNP code simulations. The technique accurately determined the activity of Cesium-137 sources, revealing lower actual activities than nominal values.

More Related Videos

Absolute Quantification of Cell-Free Protein Synthesis Metabolism by Reversed-Phase Liquid Chromatography-Mass Spectrometry
08:06

Absolute Quantification of Cell-Free Protein Synthesis Metabolism by Reversed-Phase Liquid Chromatography-Mass Spectrometry

Published on: October 25, 2019

7.5K
Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
07:41

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Published on: June 5, 2017

8.9K

Related Experiment Videos

Last Updated: Apr 23, 2026

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources
12:47

Workflow Based on the Combination of Isotopic Tracer Experiments to Investigate Microbial Metabolism of Multiple Nutrient Sources

Published on: January 22, 2018

9.0K
Absolute Quantification of Cell-Free Protein Synthesis Metabolism by Reversed-Phase Liquid Chromatography-Mass Spectrometry
08:06

Absolute Quantification of Cell-Free Protein Synthesis Metabolism by Reversed-Phase Liquid Chromatography-Mass Spectrometry

Published on: October 25, 2019

7.5K
Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
07:41

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Published on: June 5, 2017

8.9K

Area of Science:

  • Nuclear physics
  • Radiation transport modeling
  • Radiological measurements

Background:

  • Accurate source activity determination is crucial for radiation safety and calibration.
  • Existing methods may have limitations in precision for unknown sources.
  • Monte Carlo N-Particle (MCNP) code is a powerful tool for radiation transport simulation.

Purpose of the Study:

  • To develop and validate a method for calculating unknown source activity.
  • To compare calculated activities with experimental measurements.
  • To assess the accuracy of nominal activity values for calibration sources.

Main Methods:

  • Utilized experimental exposure rate measurements from an ion chamber.
  • Employed MCNP radiation transport code for theoretical exposure rate calculations.
  • Developed a fitting procedure to reconcile experimental and MCNP data by calculating an activity correction factor.

Main Results:

  • The developed method successfully calculated the activity of three Cesium-137 sources.
  • Actual source activities were found to be lower than decay-corrected nominal activities.
  • Discrepancies ranged from 3% to 10%, indicating a systematic underestimation in nominal values.

Conclusions:

  • The presented method provides a reliable approach for determining unknown source activities.
  • The findings highlight potential inaccuracies in nominal activity values for calibration sources.
  • This technique enhances the precision of radiological assessments and instrument calibration.