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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Apr 23, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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[Minimally invasive glaucoma surgery using the trabectome].

T Wecker1, J F Jordan1

  • 1Klinik für Augenheilkunde, Universitätsklinikum Freiburg.

Klinische Monatsblatter Fur Augenheilkunde
|October 2, 2014
PubMed
Summary
This summary is machine-generated.

The trabectome device effectively treats open-angle glaucoma by removing diseased tissue, lowering intraocular pressure by 30% and reducing medication needs by 42%. This minimally invasive surgery offers a safe alternative for patients with ocular surface issues.

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Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Glaucoma Research

Context:

  • Open-angle glaucoma is characterized by impaired aqueous humor outflow due to juxtacanalicular trabecular meshwork obstruction.
  • Current treatments often involve lifelong medication or more invasive surgical procedures.

Purpose:

  • To evaluate the efficacy and safety of the trabectome device for ab-interno trabeculotomy in treating open-angle glaucomas.
  • To assess the impact of trabectome surgery on intraocular pressure and topical medication requirements.

Summary:

  • The trabectome utilizes electroablation to remove diseased juxtacanalicular trabecular meshwork, restoring direct communication between the anterior chamber and Schlemm's canal collector channels.
  • Published studies demonstrate an average 30% reduction in intraocular pressure and a 42% decrease in medication usage in patients with primary and secondary open-angle glaucomas.
  • The procedure involves a clear cornea tunnel, preserving conjunctival integrity, making it suitable for patients with compromised ocular surfaces. It can be combined with phacoemulsification.

Impact:

  • Trabectome surgery offers a minimally invasive approach with a favorable complication profile, comparable to standard globe-opening surgeries.
  • This technique provides a safe and effective treatment option for patients with open-angle glaucoma requiring moderate pressure reduction.
  • The procedure shows distinct efficacy in lowering intraocular pressure and reducing medication needs, even in pseudoexfoliative glaucoma.